Preninza – F

Endometriosis and Infertility – A Simple Explanation   Endometriosis is a health problem that happens when tissue like the lining inside the uterus (called the endometrium) grows in places it shouldn’t — like on the ovaries, fallopian tubes, or other parts inside the body.  This condition affects millions of women and can sometimes make it hard for them to have babies. That’s called infertility.  Doctors rank endometriosis in four stages: mild, moderate, and severe.  Women with mild endometriosis can usually get pregnant.  In severe cases, the disease can change the shape of important organs in the body, which makes it harder to become pregnant.  Some scientists think that women with endometriosis may be missing a special enzyme that helps a baby attach to the uterus, which is important for a normal pregnancy.  Doctors have different ideas about how endometriosis causes infertility. It may:  Change hormone levels  Damage or move body parts inside the pelvis  Make the area unhealthy for eggs or sperm  Affect how the immune system works  Sadly, infertility is one of the hardest parts of having endometriosis. And it comes along with the pain many women feel because of the disease.  But there is hope! Many women with endometriosis can still become mothers with the right help. Treatments include:  Hormone medicine  Healthier eating and lifestyle  Surgery to fix any damage  IVF (in vitro fertilization) – where the baby starts growing outside the body and is placed in the uterus  So even though endometriosis can be tough, there are ways to treat it, and many women still go on to have healthy babies.    New Discovery About Male Infertility    Scientists at Newcastle University have made an important discovery that helps us understand why some men can’t have children.  They found a new genetic cause of severe male infertility. This discovery brings hope that better treatments may be available in the future.  The study, published in a science journal called Nature Communications, shows that:  Some men become infertile because of new mutations in their genes.  These mutations are not inherited from their parents.  Instead, they happen during the process when the parents’ DNA is copied to create a baby.  This means the problem doesn’t come directly from the mother or father’s DNA — it happens when their DNA is being passed on to their child.  Professor Joris Weltman, the lead scientist from Newcastle University, said:  “Right now, we don’t know the cause of infertility for most men. But our study helps explain the reason for some of them, and we hope to help even more in the future.”  This research involved patients from the UK and the Netherlands, and it may one day help more men find answers and treatment options when they are trying to have children.    Minimally Invasive Treatment Could Help More Women Conceive Naturally   New research has found that many women struggling with infertility caused by blocked fallopian tubes may not need complex fertility treatments. A simple, minimally invasive procedure known as fallopian tube recanalization could help them conceive naturally.  This approach involves:  A basic diagnostic test to check for blockages in the fallopian tubes.  If a blockage is found, doctors use image-guided tools to gently open the tube — without surgery and with little discomfort.  The procedure is performed by specialists in interventional radiology and is usually done on an outpatient basis, meaning patients can go home the same day.  Dr. Lindsay Machan, associate professor at the University of British Columbia and lead author of the study, explains:  “Most women with blocked fallopian tubes could have their condition easily corrected. This treatment gives them real options and, in many cases, a chance to conceive without more invasive procedures.”  This breakthrough offers hope to many couples trying to start a family. By exploring simpler solutions first, women can make better-informed decisions about their fertility journey.    Lagging Chromosomes: A Hidden Cause of Infertility    One lesser-known but important cause of infertility is a problem called lagging chromosomes.  During reproduction, our bodies must copy and divide DNA perfectly to create healthy eggs and sperm. Sometimes, this process doesn’t go smoothly. In some cases, chromosomes — which carry our genetic information — don’t move correctly during cell division. This is called chromosomal lagging.  When chromosomes lag or move too slowly, they may:  End up in the wrong place,  Get left behind, or  Be divided unevenly between cells.  This can lead to genetic errors in eggs or sperm, which may result in:  Embryos that cannot develop properly,  Early miscarriages, or  Difficulty in getting pregnant at all.  Lagging chromosomes are especially common in older eggs, which is why fertility naturally declines with age, especially in women over 35. However, it can also happen in younger individuals due to genetic or environmental factors.  Can It Be Detected or Treated?  Lagging chromosomes can sometimes be identified through advanced fertility testing like:  Preimplantation genetic testing (PGT) during IVF,  Chromosome studies on embryos, eggs, or sperm.  While we cannot always prevent chromosomal lagging, lifestyle changes, managing underlying health conditions, and seeking early fertility evaluation can help improve chances of a healthy pregnancy.